Analytical validation of an error-corrected ultra-sensitive ctDNA next-generation sequencing assay
نویسندگان
چکیده
منابع مشابه
Analytical validation of a next generation sequencing liquid biopsy assay for high sensitivity broad molecular profiling
Circulating tumor DNA (ctDNA) analysis is being incorporated into cancer care; notably in profiling patients to guide treatment decisions. Responses to targeted therapies have been observed in patients with actionable mutations detected in plasma DNA at variant allele fractions (VAFs) below 0.5%. Highly sensitive methods are therefore required for optimal clinical use. To enable objective asses...
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ژورنال
عنوان ژورنال: BioTechniques
سال: 2020
ISSN: 0736-6205,1940-9818
DOI: 10.2144/btn-2020-0045